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KMID : 1143220220650060487
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Obstetrics & Gynecology Science
2022 Volume.65 No. 6 p.487 ~ p.501
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COVID-19 and vaccination during pregnancy: a systematic analysis using Korea National Health Insurance claims data
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Ahn Ki-Hoon
Kim Hae-In
Lee Kwang-Sig
Heo Ju-Sun
Kim Ho-Yeon
Cho Geum-Joon
Hong Soon-Cheol
Oh Min-Jeong
Kim Hae-Joong
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Abstract
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Objective: This study systematically analyzed coronavirus disease 2019 (COVID-19) and vaccination details during pregnancy by using the national health insurance claims data.
Methods: Population-based retrospective cohort data of 12,399,065 women aged 15-49 years were obtained from the Korea National Health Insurance Service claims database between 2019 and 2021. Univariate analysis was performed to compare the obstetric outcomes of pregnant women (ICD-10 O00-O94) and their newborns (ICD-10 P00-P96) with and without COVID-19. Univariate analysis was also performed to compare the age and obstetric outcomes of pregnant women receiving different types of vaccines.
Results: The percentage of pregnant women with COVID-19 during pregnancy was 0.11%. Some obstetric outcomes of pregnant women with COVID-19, including the rates of preterm birth or cesarean delivery, were significantly better than those of pregnant women without COVID-19. The rate of miscarriage was higher in pregnant women with COVID-19 than without COVID-19. However, the outcomes of newborns of women with and without COVID-19 were not significantly different. Regarding vaccination type, obstetric outcomes of pregnant women appeared to be worse with the viral vector vaccine than with the mRNA vaccine.
Conclusion: To the best of our knowledge, this is the first study to systematically analyze COVID-19 and vaccination details during pregnancy using the national health insurance claims data in Korea. The obstetric outcomes in pregnant women with and without COVID-19 and their newborns were similar.
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KEYWORD
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COVID-19, Vaccination, Pregnancy, Infant, newborn, Pregnancy outcome
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